Interplay between Sumoylation and Phosphorylation for Protection against α-Synuclein Inclusions*
Identifieur interne : 000A25 ( Main/Exploration ); précédent : 000A24; suivant : 000A26Interplay between Sumoylation and Phosphorylation for Protection against α-Synuclein Inclusions*
Auteurs : Hedieh Shahpasandzadeh ; Blagovesta Popova ; Alexandra Kleinknecht ; Paul E. Fraser ; Tiago F. Outeiro ; Gerhard H. BrausSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.
English descriptors
- KwdEn :
- Autophagy, Chromatography, Affinity, G-Protein-Coupled Receptor Kinase 5 (metabolism), Humans, Lewy Bodies (metabolism), Lysine (chemistry), Microscopy, Fluorescence, Phosphorylation, Plasmids (metabolism), Proteasome Endopeptidase Complex (metabolism), Protein Binding, Protein Processing, Post-Translational, Protein-Serine-Threonine Kinases (metabolism), Saccharomyces cerevisiae (metabolism), Sumoylation, Ubiquitin (chemistry), alpha-Synuclein (metabolism).
- MESH :
- chemical , chemistry : Lysine, Ubiquitin.
- chemical , metabolism : G-Protein-Coupled Receptor Kinase 5, Proteasome Endopeptidase Complex, Protein-Serine-Threonine Kinases, alpha-Synuclein.
- metabolism : Lewy Bodies, Plasmids, Saccharomyces cerevisiae.
- Autophagy, Chromatography, Affinity, Humans, Microscopy, Fluorescence, Phosphorylation, Protein Binding, Protein Processing, Post-Translational, Sumoylation.
Abstract
Url:
DOI: 10.1074/jbc.M114.559237
PubMed: 25231978
PubMed Central: 4223324
Affiliations:
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Le document en format XML
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Fraser</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Outeiro, Tiago F" sort="Outeiro, Tiago F" uniqKey="Outeiro T" first="Tiago F." last="Outeiro">Tiago F. Outeiro</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Braus, Gerhard H" sort="Braus, Gerhard H" uniqKey="Braus G" first="Gerhard H." last="Braus">Gerhard H. Braus</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25231978</idno><idno type="pmc">4223324</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223324</idno><idno type="RBID">PMC:4223324</idno><idno type="doi">10.1074/jbc.M114.559237</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000578</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000578</idno><idno type="wicri:Area/Pmc/Curation">000578</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000578</idno><idno type="wicri:Area/Pmc/Checkpoint">000461</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000461</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000639</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000639</idno><idno type="wicri:Area/PubMed/Curation">000639</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000639</idno><idno type="wicri:Area/PubMed/Checkpoint">000639</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000639</idno><idno type="wicri:Area/Ncbi/Merge">001908</idno><idno type="wicri:Area/Ncbi/Curation">001908</idno><idno type="wicri:Area/Ncbi/Checkpoint">001908</idno><idno type="wicri:doubleKey">0021-9258:2014:Shahpasandzadeh H:interplay:between:sumoylation</idno><idno type="wicri:Area/Main/Merge">000A28</idno><idno type="wicri:Area/Main/Curation">000A25</idno><idno type="wicri:Area/Main/Exploration">000A25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Interplay between Sumoylation and Phosphorylation for Protection against α-Synuclein Inclusions<xref ref-type="fn" rid="FN1">*</xref></title><author><name sortKey="Shahpasandzadeh, Hedieh" sort="Shahpasandzadeh, Hedieh" uniqKey="Shahpasandzadeh H" first="Hedieh" last="Shahpasandzadeh">Hedieh Shahpasandzadeh</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Popova, Blagovesta" sort="Popova, Blagovesta" uniqKey="Popova B" first="Blagovesta" last="Popova">Blagovesta Popova</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Kleinknecht, Alexandra" sort="Kleinknecht, Alexandra" uniqKey="Kleinknecht A" first="Alexandra" last="Kleinknecht">Alexandra Kleinknecht</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Fraser, Paul E" sort="Fraser, Paul E" uniqKey="Fraser P" first="Paul E." last="Fraser">Paul E. Fraser</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Outeiro, Tiago F" sort="Outeiro, Tiago F" uniqKey="Outeiro T" first="Tiago F." last="Outeiro">Tiago F. Outeiro</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Braus, Gerhard H" sort="Braus, Gerhard H" uniqKey="Braus G" first="Gerhard H." last="Braus">Gerhard H. Braus</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autophagy</term><term>Chromatography, Affinity</term><term>G-Protein-Coupled Receptor Kinase 5 (metabolism)</term><term>Humans</term><term>Lewy Bodies (metabolism)</term><term>Lysine (chemistry)</term><term>Microscopy, Fluorescence</term><term>Phosphorylation</term><term>Plasmids (metabolism)</term><term>Proteasome Endopeptidase Complex (metabolism)</term><term>Protein Binding</term><term>Protein Processing, Post-Translational</term><term>Protein-Serine-Threonine Kinases (metabolism)</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Sumoylation</term><term>Ubiquitin (chemistry)</term><term>alpha-Synuclein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Lysine</term><term>Ubiquitin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>G-Protein-Coupled Receptor Kinase 5</term><term>Proteasome Endopeptidase Complex</term><term>Protein-Serine-Threonine Kinases</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lewy Bodies</term><term>Plasmids</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Autophagy</term><term>Chromatography, Affinity</term><term>Humans</term><term>Microscopy, Fluorescence</term><term>Phosphorylation</term><term>Protein Binding</term><term>Protein Processing, Post-Translational</term><term>Sumoylation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Phosphorylation and sumoylation are post-translational modifications of the Parkinson disease protein α-synuclein.</p><p><bold>Results:</bold> α-Synuclein inclusion clearance is impaired in yeast when sumoylation is inhibited; phosphorylation of α-synuclein can compensate SUMO impairment.</p><p><bold>Conclusion:</bold> Sumoylation stimulates autophagy clearance of α-synuclein inclusions, whereas phosphorylation promotes autophagy and proteasome degradation.</p><p><bold>Significance:</bold> A complex molecular post-translational cross-talk is required in yeast to clear toxic inclusions.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Braus, Gerhard H" sort="Braus, Gerhard H" uniqKey="Braus G" first="Gerhard H." last="Braus">Gerhard H. Braus</name><name sortKey="Fraser, Paul E" sort="Fraser, Paul E" uniqKey="Fraser P" first="Paul E." last="Fraser">Paul E. Fraser</name><name sortKey="Kleinknecht, Alexandra" sort="Kleinknecht, Alexandra" uniqKey="Kleinknecht A" first="Alexandra" last="Kleinknecht">Alexandra Kleinknecht</name><name sortKey="Outeiro, Tiago F" sort="Outeiro, Tiago F" uniqKey="Outeiro T" first="Tiago F." last="Outeiro">Tiago F. Outeiro</name><name sortKey="Popova, Blagovesta" sort="Popova, Blagovesta" uniqKey="Popova B" first="Blagovesta" last="Popova">Blagovesta Popova</name><name sortKey="Shahpasandzadeh, Hedieh" sort="Shahpasandzadeh, Hedieh" uniqKey="Shahpasandzadeh H" first="Hedieh" last="Shahpasandzadeh">Hedieh Shahpasandzadeh</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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